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Dying white blood cells have been captured on film for the first time, showing them alerting their neighbouring cells to their plight.
Scientists from La Trobe University in Melbourne, Australia used timelapse photography to film the dying cells, which are the human immune system's first-line defence against bacteria, fungal infections and viruses.
Previously, it was thought that cells died and fell apart randomly. However, the footage revealed the cells ejecting molecules from inside themselves -- indicating a far more controlled and complex process. The research, published in the medical journal Nature Communications, found that cell death happens in three distinct stages: bulging, exploding and, finally, breaking apart.
Georgia Atkin-Smith, a cell biologist and co-leader of the team -- which also included researchers from the University of Virginia -- explained: "When the cell starts to die it forms these lumps which push outwards and when the cell then explodes, it shoots out long 'beaded' protrusions which look like a necklace, which then breaks apart into individual 'beads'."
She continued: "The cells around them can easily engulf these smaller pieces. But we also think there are certain molecules in the beads that, when eaten by a live cell, can signal back a warning to other white blood cells to say 'Look out, there may be a pathogen coming to get you'".
The breakthrough discovery has given scientists a clearer idea exactly of how pathogens invade dying cells and help to spread disease further. It's hoped that the study may give scientists a better understanding of how the body's healing mechanisms work, leading to improved treatment for diseases.
This article was originally published by WIRED UK
