As the artist Wayne Dorrington mentions, he's not suggesting Wil Wheaton is THE messiah, but Wil's customary open-handed show opening along with having his friends seated around the table just begged for the Da Vinci's Last Supper treatment for many of the great, geeky guests on Tabletop.
For handy reference, seated left to right are Colin Ferguson, Riki Lindhome, Kate Micucci, Steve Jackson, Alison Haislip, Anne Wheaton, Wil Wheaton, Grant Imahara, Felicia Day (with Dr. Hannah), Bonnie Burton, Phil LaMarr, Beth Riesgraf and Bill Prady.
Special props to GeekDad Nathan for noticing that the representation of Wil's wife, Anne, is pounding the table and the Ticket to Ride playing pieces are flying, as did happen in a very memorable episode.